849-3 Extracellular matrix remodeling during left ventricular assist device support: Relation between collagen and passive pressure-volume relations
نویسندگان
چکیده
منابع مشابه
Ventricular unloading, tissue angiotensin II, matrix modulation, and function during left ventricular assist device support.
eart failure (HF) has become the major epidemic of the ew millennium, and use of the left ventricular (LV) assist evice (LVAD) for mechanical support in end-stage HF is ncreasing. Introduced as an alternative to heart transplanation, LVADs were approved by the Food and Drug dministration a decade ago to provide a bridge to translantation in the moribund end-stage HF patient waiting or a donor h...
متن کاملMechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness.
BACKGROUND Left ventricular assist devices (LVADs) induce reverse remodeling of the failing heart except for the extracellular matrix, which exhibits additional pathophysiological changes, although their mechanisms and functional consequences are unknown. METHODS AND RESULTS Hearts were obtained at transplant from patients with idiopathic dilated cardiomyopathy (DCM) not requiring LVAD suppor...
متن کاملSarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support.
BACKGROUND Left ventricular assist devices (LVADs) implanted in patients with severe congestive heart failure (CHF) as a bridge to transplantation have been shown to reverse chamber enlargement, regress cellular hypertrophy, and increase contractility. The purpose of this study was to gain a better understanding of the molecular changes associated with increased contractility after LVAD support...
متن کاملLeft ventricular assist device-induced reverse ventricular remodeling.
Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart ...
متن کاملBlood pressure and adverse events during continuous flow left ventricular assist device support.
BACKGROUND Adverse events (AEs), such as intracranial hemorrhage, thromboembolic event, and progressive aortic insufficiency, create substantial morbidity and mortality during continuous flow left ventricular assist device support yet their relation to blood pressure control is underexplored. METHODS AND RESULTS A multicenter retrospective review of patients supported for at least 30 days and...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(04)90958-8