808-4 Exaggeration of neointimal hyperplasia following stent deployment in type B bifurcation lesions

Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis.

BACKGROUND Despite limiting elastic recoil and late vascular remodeling after angioplasty, coronary stents remain vulnerable to restenosis, caused primarily by neointimal hyperplasia. Paclitaxel, a microtubule-stabilizing drug, has been shown to inhibit vascular smooth muscle cell migration and proliferation contributing to neointimal hyperplasia. We tested whether paclitaxel-coated coronary st...

Intravascular sonotherapy decreases neointimal hyperplasia after stent implantation in swine.

BACKGROUND Intimal hyperplasia and subsequent in-stent restenosis remain a major limitation after stent implantation. In vitro cell culture studies show that low-frequency, noncavitational ultrasound energy may impact smooth muscle cell proliferation. Accordingly, we assessed the efficacy of intravascular sonotherapy treatment on intimal hyperplasia in a swine stent model. METHODS AND RESULTS...

Stent treatment of coronary artery bifurcation lesions.

In percutaneous coronary interventions (PCIs), the treatment of bifurcation lesions is a challenge to the interventional cardiologist. PCI operators, in general, use the term coronary artery bifurcation (from latin furca 1⁄4 fork, branch): (i) when a coronary artery divides into two equally important branches or (ii) when a main branch gives away a side branch, which is large enough to be of ha...

Antiplatelet therapy following stent deployment.

Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation.

BACKGROUND Patterns of arterial remodeling during the course of plaque development have been shown to play an important role in both the progression of de novo atherosclerosis and in the restenotic process following coronary intervention. The aim of the present prospective study was to evaluate the effect of pre-interventional arterial remodeling on in-stent neointimal hyperplasia (NIH) and in-...