793-4 Local Delivery of C-myb Antisense attenuates Neo-Intimal Thickening in a Porcine Model of Coronary Angioplasty
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چکیده
منابع مشابه
Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries.
Previous studies have shown that inhibition of the proto-oncogene c-myb inhibits neointimal formation in various animal models. However, the temporal and spatial expression of c-Myb in the vessel wall after injury is not known, and the mechanism of action of antisense oligonucleotide (AS-ODN-c-myb) inhibition remains unclear. One potential effect of cell cycle dysregulation by inhibition of c-m...
متن کاملInhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries
Adelman, James Chesebro, John Fallon, Valentin Fuster, Andrew Marks and Juan José Richard Gallo, Adrian Padurean, Thottala Jayaraman, Steven Marx, Merce Roque, Steven by Targeting Regulators of the Cell Cycle Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All ...
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including atherectomy, endarterectomy, and vein or synthetic bypass grafting. These procedures all have in common an element of injury and a subsequent response of the vascular wall to that injury. The accumulation of vascular smooth muscle cells and associated matrix invariably accounts for the bulk of the intimal hyperplastic lesion. For this reason, clinical investigators have focused on pha...
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BACKGROUND Although percutaneous transluminal coronary angioplasty (PTCA) is a highly effective procedure to reduce the severity of stenotic coronary atherosclerotic disease, its long-term success is significantly limited by the high rate of restenosis. Several cellular and molecular mechanisms have been implicated in the development of restenosis post-PTCA, including vascular smooth muscle cel...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)93020-d