792 Tea oil concentrate from camellia oleifera, obtained by molecular distillation, to improve skin comfort and well-being

Psychological stress has multiple physiologic and clinical impacts on skin such as inflammation, itching, impair barrier function, provoking discomfort that can amplify psychological stress. We have developed a new active ingredient from Camellia oleifera seeds, tea oil concentrate (TOC), rich in unsaponifiable fraction. This was evaluated vitro models mimicking the effects of skin. The effect TOC IL1a release reconstructed human epidermises (RHE) stimulated by PMA. To assess he activity neurosensory system, applied reinnervated substance P measured ELISA following lactic acid provocation. efficacy also investigated cortisol explants adrenocorticotropic hormone (ACTH) temperature. finally studied function subjected to stripping Our results show significantly inhibited production induced PMA RHE model. able decrease epidermis Moreover, decreased ACTH temperature explant showed an model barrier. Finally, lucifer yellow permeability, indicating better integrity. conclude, our is inhibit mediators involved two response axis (cortisol P). it shows anti-inflammatory protect against Taken together, these potential stop vicious circle promote comfort.