774. Evaluation of Adenovirus Vectors Containing Serotype 35 Fibers for Gene Therapy of Cervical Cancer
نویسندگان
چکیده
منابع مشابه
Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35.
The capacity of gene delivery vehicles is considered to be a critical factor determining the success of gene therapy. To date, various types of gene delivery vehicle have been developed. Among them, recombinant adeno-virus (Ad) vectors have potential that has favored their worldwide use in vitro and in vivo. Conventional Ad vectors are composed of subgroup C Ad serotype 5 (Ad5), although it has...
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Objective(s) Recombinant adenoviruses are currently used for a variety of purposes, including in vitro gene transfer, in vivo vaccination, and gene therapy. Ability to infect many cell types, high efficiency in gene transfer, entering both dividing and non dividing cells, and growing to high titers make this virus a good choice for using in various experiments. In the present experiment, a reco...
متن کامل[Characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates].
Recombinant Adenovirus (Ad) vectors are considered to be a promising gene delivery vehicle of high utility because they are easy to construct, can be produced at high titers, and efficiently transduce various types of cells. Ad vectors commonly used in the world, including clinical trials, are composed of Ad serotype 5 (Ad5), which belongs to subgroup C. In recent years, however, it has become ...
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Ovarian cancer is the leading cause of death from gynecologic malignancies and, although conventional chemotherapy provides some initial positive response, drug resistance can often occur within months. Thus, it is not surprising that other strategies are sought, and a number of groups have used virus gene therapy as one possible route to supplement conventional chemotherapy. Adenovirus vectors...
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Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates fo...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2006
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2006.08.860