762: Fetal baroreceptor activity in preterm fetal sheep with lipopolysaccharide- induced endotoxemia
نویسندگان
چکیده
منابع مشابه
Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep.
OBJECTIVE Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalogr...
متن کاملEndotoxin-induced maturation of monocytes in preterm fetal sheep lung.
The fetal lung normally contains immature monocytes and very few mature macrophages. The chorioamnionitis frequently associated with preterm birth induces monocyte influx into the fetal lung. Previous studies demonstrated that monocytes in the developing lung can mediate lung injury responses that resemble BPD in humans. We hypothesized that chorioamnionitis would induce maturation of immature ...
متن کاملBiphasic changes in fetal heart rate variability in preterm fetal sheep developing hypotension after acute on chronic lipopolysaccharide exposure.
Perinatal exposure to infection is highly associated with adverse outcomes. Experimentally, acute, severe exposure to gram-negative bacterial lipopolysaccharide (LPS) is associated with increased fetal heart rate variability (FHRV). It is unknown whether FHRV is affected by subclinical infection with or without acute exacerbations. We therefore tested the hypothesis that FHRV would be associate...
متن کاملEffect of intra-amniotic lipopolysaccharide on nephron number in preterm fetal sheep.
Chorioamnionitis is an antecedent of preterm birth. We aimed to determine the effect of experimental chorioamnionitis in fetal sheep during late gestation on 1) nephron number, 2) renal corpuscle volume, and 3) renal inflammation. We hypothesized that exposure to chorioamnionitis would lead to inflammation in fetal kidneys and adversely impact on the development of nephrons, leading to a reduct...
متن کاملSubclinical decelerations during developing hypotension in preterm fetal sheep after acute on chronic lipopolysaccharide exposure
Subclinical (shallow) heart rate decelerations occur during neonatal sepsis, but there is limited information on their relationship with hypotension or whether they occur before birth. We examined whether subclinical decelerations, a fall in fetal heart rate (FHR) that remained above 100 bpm, were associated with hypotension in preterm fetal sheep exposed to lipopolysaccharide (LPS). Chronicall...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2019
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2018.11.785