749The global prevalence of Rheumatoid Arthritis: A meta-analysis

Abstract Background To determine the global prevalence of rheumatoid arthritis (RA) based on published studies and reveal factors which influence RA estimates. Methods Four electronic databases- ProQuest Central, MEDLINE, Web Science, EMBASE were searched for publications from 1980 2019, reporting estimates RA. A random-effect meta-analysis model was used to produce pooled The potential sources between-study heterogeneity identified using sensitivity analysis, sub-group meta-regression analyses. Results total 67 consisting 212,335,171 patients included in meta-analysis. estimated 0.46% (95% CI: 0.39-0.54; I2=99.9%) with a 95% prediction interval (0.06–1.27). point-prevalence 0.45% 0.38- 0.53%), while period-prevalence (0.36% 0.57%). highest at 0.69% 0.47–0.95) derived linked data studies. Based subgroup analyses, influenced by geographical location, risk bias studies, method urban population setting over stratified periods. Conclusion 460 per 100,000 1980–2018, (0.06– 1.27%). assessment time. Key messages