7-(2-Aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

A new parenteral cephalosporin, SK&F 59962: 7-trifluoromethylthioacetamido-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid. Chemistry and structure activity relationships.

The synthesis, microbiological profile and in vivo effectiveness in laboratory animals of a series of cephalosporins having 7-acyl substituents derived from methylthioacetic acid are described. Structure-activity relationships examined include the effect of oxidation of the side-chain sulfur atom, replacement of the (side-chain) methyl hydrogens by fluorine and replacement of the 3-acetoxy subs...

(6R,7R)-3-Hydroxymethyl-7-(2-phenyl­acetamido)-3-cephem-4-carboxylic acid lactone

In the title compound {systematic name: N-[(4R,5R)-3,11-dioxo-10-oxa-6-thia-2-aza-tricyclo-[6.3.0.0(2,5)]undec-1(8)-en-4-yl]-2-phenyl-acetamide}, C(16)H(14)N(2)O(4)S, the four- and five-membered rings adopt planar conformations (with r.m.s. deviations of 0.0349 and 0.0108 Å respectively) while the six-membered ring adopts a half-chair, or envelope-like, conformation with the S atom in the flap ...

Isolation of 7 beta-(5-hydroxy-5-carboxyvarelamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid from streptomyces sp.

Application of 4-Chlorobutyryl Group as Amino Protective Group in the Synthesis of 7-(D-2-Amino-2-phenylacetamido)-3- -methyl-3-cephem-4-carboxylic Acid (Cephalexin)*

4-Chlorobutyryl group was used as amino protective group for n(-)-alpha-phenylglycine (I). N-Hydroxysuccinimide ester III was prepared in high yield but partly racemic. Reaction of III or IV with V afforded epimeric mixtures of N,0-protected cephalexins (VI), which can be separated by crystallisation. The 4-chlorobutyryl group in VII was removed under very mild conditions giving cephalexin (IX)...

1-Cyclo­hexyl-2-(3-fur­yl)-1H-benzimidazole-5-carboxylic acid

The asymmetric unit of the title compound, C(18)H(18)N(2)O(3), contains two mol-ecules. The fused rings of both mol-ecules are almost planar, with dihedral angles of 3.1 (1) and 2.8 (2)° between the fused rings. The furan rings are rotated by 43.85 (15) and -21.07 (9)° with respect to the planes of the attached bnzimidazole systems. In the crystal, mol-ecules are linked into infinite chains by ...