64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
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چکیده
منابع مشابه
64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
BACKGROUND The aim of this study was to compare (64)Cu-diacetyl-bis(N(4)-methylsemicarbazone) ((64)Cu-ATSM) and (18)FDG PET uptake characteristics and (64)Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. METHODS Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of (64)C...
متن کاملCu-ATSM and FDG PET uptake and Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
Background: The aim of this study was to compare Cu-diacetyl-bis(N-methylsemicarbazone) (Cu-ATSM) and FDG PET uptake characteristics and Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. Methods: Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of Cu-ATSM and pimonidazole...
متن کاملautoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
Background: The aim of this study was to compare Cu-diacetyl-bis(N-methylsemicarbazone) (Cu-ATSM) and FDG PET uptake characteristics and Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. Methods: Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of Cu-ATSM and pimonidazole...
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UNLABELLED Tumor uptake of copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) (copper-ATSM), a hypoxia-targeting radiopharmaceutical, assessed by PET has been found to correlate with prognosis in several human cancers. Wide clinical utility of this tracer will require its labeling with a copper radionuclide having a longer half-life than the (60)Cu used in studies to date. The purpose of thi...
متن کاملCardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.
UNLABELLED Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current approaches are insufficiently sensitive for clinical use. The PET tracer copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) ((64)Cu-ATSM) has promise, but its selectivity and sensitivity could be improved by structural modification. We have therefore evaluated a range of (64)Cu-ATSM analogs...
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ژورنال
عنوان ژورنال: Radiation Oncology
سال: 2012
ISSN: 1748-717X
DOI: 10.1186/1748-717x-7-89