630 Cdk2: A marker for invasive melanoma

Background: Although cyclin-dependent kinase 2 (CDK2) is known to be upregulated in certain cancers, its spatial expression pattern melanocytic tumors has remained unknown. Objective: To characterize CDK2 benign and malignant proliferations. Methods: We performed immunohistochemistry (IHC) on normal skin a tumor panel comprising over 200 congenital nevi, dysplastic melanomas situ, invasive melanomas. recorded their staining patterns, intensities, compared these of melanoma marker PRAME (Preferentially expressed Antigen Melanoma). Results: Serial antibody dilutions revealed that IHC reliably stains dermal-epidermal junction melanocytes both lesional non-lesional skin. Melanocytic nevi progressively lost the dermis (>90%), whereas retained strong aspects (>90%). were highly correlated melanoma. Conclusion: by deep dermis, suggesting putative role during melanomagenesis. Deep dermal positivity specific sensitive for melanoma, thus, may useful ancillary test diagnosing challenging tumors.