612 Theabrownin in black tea suppresses UVB-induced MMP-1 expression in HaCaT keratinocytes

Theabrownin is a heterogeneous polyphenolic compound, obtained from fermented dark teas, with many bioactive functions. However, the role of theabrownin in skin photoaging remains unclear. In this study, we investigated whether modulates ultraviolet B (UVB)-induced matrix metalloprotease-1 (MMP-1) expression HaCaT keratinocytes. exerted antioxidant properties, which resulted scavenging intracellular reactive oxygen species generated by UVB irradiation cells. Consequently, inhibited UVB-induced extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal (JNK) phosphorylation, are activated oxidative stress. also suppressed downstream signaling pathway mitogen-activated protein (MAPK) nuclear accumulation activator protein-1 (AP-1), an essential transcription factor for UVB-stimulated MMP-1 expression. Based on these results, conclude that can serve as novel anti-photoaging compound skin.