60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth
نویسندگان
چکیده
منابع مشابه
N-terminal POMC peptides and adrenal growth
The peptide hormones contained within the sequence of proopiomelanocortin (POMC) have diverse roles ranging from pigmentation to regulation of adrenal function to control of our appetite. It is generally acknowledged to be the archetypal hormone precursor, and as its biology has been unravelled, so too have many of the basic principles of hormone biosynthesis and processing. This short review f...
متن کامل60 YEARS OF POMC: POMC: an evolutionary perspective.
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizati...
متن کامل60 YEARS OF POMC: POMC: the consummate peptide hormone precursor.
editorial 60 years of POMC a j l clark and p lowry 56:4 E1–E2 Proopiomelanocortin (POMC) has been at the forefront of molecular endocrinology for the past 60 years, and the concepts derived from POMC research have led the way in understanding a wide range of endocrine systems. In this issue, we celebrate this enormous body of work with contributions from an outstanding faculty of contributors, ...
متن کامل60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH.
The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo-pituitary-adrenal axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on ACTH receptor properties, the first part of the review covers the role of ACTH in steroidogenesis and steroid secretion. We highlight the...
متن کامل60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression.
Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that reflect the developmental history of POMC-expressing cells of the pituitary and hypothalamus, as well as their critical role in the endocrine system. These inputs are integrated at specific regulatory sequences within the promoter and pituitary or hypothalamic enhancers of the POMC locus. Investigations of develo...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2016
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-15-0269