6β-hydroxycortisol:a marker for hepatic enzyme inhibition by lead
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منابع مشابه
Inhibition of hepatic-induced enzyme formation by 8-azaguanine.
A body of evidence has accumulated which indicates that the :purine analogue, 8-azaguanine, has an inhibitory action upon protein synthesis. It has been shown in several laboratories that the production of certain inducible bacterial enzymes may be inhibited by this agent (14). It has also been reported by Mandel (5) that utilization of methionine-Ss5 and cystine-S35 for protein synthesis was m...
متن کاملLead inhibition of enzyme synthesis in soil.
Addition of 2 mg of Pb2+/g of soil concident with or after amendment with starch or maltose resulted in 75 and 50% decreases in net synthesis of amylase and alpha-glucosidase, respectively. Invertase synthesis in sucrose-amended soil was transiently reduced after Pb2+ addition. Amylase activity was several times less sensitive to Pb2+ inhibition than was enzyme synthesis. In most cases, the rat...
متن کاملEx situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.
The disposition of digoxin and the influence of the organic anion transporting polypeptide (Oatp)2 inhibitor rifampicin and the P-glycoprotein (P-gp) inhibitor quinidine on its hepatic disposition were examined in the isolated perfused rat liver. Livers from groups of rats were perfused in a recirculatory manner after a bolus dose of digoxin (10 microg), a dual substrate for Oatp2 and P-gp as w...
متن کاملENZYME INHIBITION BY HERBAL MOLLUSCICIDES IN THE NERVOUS TISSUE OF THE SNAIL LYMNAEA ACUMINATA
The effect of Annona squamosa, Lawsonia inermis and their combination with other herbal molluscicides were studied on different enzyme activity in the nervous tissue of Lymnaea acuminata. Twenty-Four hour in vivo exposure to 40% and 80% of 24 h LC50 of plant derived molluscicides and their combination with other molluscicides such as Cedrus deodara, Azadirachta indica oil, Allium sativum, Polia...
متن کاملInhibition of Cyclooxygenase Type 1 and 2 Enzyme by Aqueous Extract of Elaeagnus Angustifolia in Mice
Introduction: It has been shown that the extract of Elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. The aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of Elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (Cox) type ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198112000-00219