منابع مشابه
MANIFESTATIONS OF TOXICITY Organ Toxicity
The discipline of toxicology considers the adverse effects of chemicals, including drugs, and other agents, such as biological toxins and radiation, on biological systems. Toxicity associated with drug action can generally be characterized as either an extension of the therapeutic effect, such as the fatal central nervous system (CNS) depression that may follow a barbiturate overdose, or as an ...
متن کاملMercury toxicity
Mercury is a metal found in elemental, organic, and inorganic forms in the nature. This substance is present in the composition of earth crust, soil, air, and even in some tissues of plants and sea animals. Each year nearly 3400 tons of mercury compounds are released in the environment, which 95% settle in the soil, 3% in the oceans, and 2% in the atmosphere. Different industrial products li...
متن کاملAcute toxicity.
1. Inventory of methods currently available From the regulatory point of view, the main objective of acute toxicity testing is basically to classify chemicals according to their intrinsic toxicity as required by the EEC directive on classification, packaging, and labelling of dangerous substances (Council Directive 67/548/EEC and subsequent amendments). This requirement aims to protect public h...
متن کاملSelective Toxicity
The eleven essays cover the following subjects: Inflammation and Tissue Injury, by Ward; Cellular Basis of Immunoglobulin Synthesis, by Mullinax; Immunoglobin Structure and Biological Implications, by Bennett; Molecular Aspects of Antigen-Antibody Binding as Related to the Initiation of Immunological Reactions, by Siskind and Levine; Complement Components, by Stroud; Complement and Its Role in ...
متن کاملMitochondrial Toxicity
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creating a large number of potential gene-environment interactions in mitochondrial toxicity. We briefly review this history, and then highlight c...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 2017
ISSN: 0388-1601,1882-8272
DOI: 10.3999/jscpt.48.79