#5876 ISLET TRANSPLANTATION VERSUS INSULIN ALONE IN TYPE 1 DIABETIC KIDNEY TRANSPLANT RECIPIENTS: A FRENCH NATIONWIDE STUDY ON BEHALF OF THE TREPID GROUP
نویسندگان
چکیده
Abstract Background and Aims Islet transplantation is associated with a benefit on glycaemic control compared to optimized insulin therapy in recent clinical trials. However, there lack of evidence concerning the long-term impact islet type 1 diabetic kidney transplant recipients’ prognosis. Method Every recipient transplanted France between 2000 2017 was included. Patients pancreatic islets were controls treated alone according matching method based time-dependent propensity scores (using following variables : yera transplantation, donor age, serum creatinine, HBA1c, BMI, cardiovascular background) which allow ensure patients comparability at time transplantation. The primary outcome graft failure, defined by death or return dialysis. Results Among 2393 during study period, 381 eligible including 47 that actually islets. Median for 34.8 months [21.8-48.4]. Probabilities insulino-independence survival 1, 5 10 years respectively 63.8% [51.5-79.2], 46.3% [33.9-63.2], 38.7% [25.9-57.8] 89.4% [81.0-98.6], 87.2% [78.2-97.3], 78.2% [66.2-92.4]. After matching, we observed significant HR 0.48 [0.20-0.94], mainly explained protective effect risk (HR = 0.38 [0.11-0.95]). We finally estimated life-expectancy 10-year follow-up found 9.61 [9.02-10.00] group versus 8.85 [7.97-9.56], difference 8.88 [-2.16-20.44] Conclusion observe failure recipients. These results provide incentives promote this population.
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_5876