α5β1 Integrin Engagement Increases Large Conductance, Ca2+-activated K+ Channel Current and Ca2+ Sensitivity through c-src-mediated Channel Phosphorylation*
نویسندگان
چکیده
منابع مشابه
Large conductance Ca2+-activated K+ (BK) channel: activation by Ca2+ and voltage.
Large conductance Ca2+-activated K+ (BK) channels belong to the S4 superfamily of K+ channels that include voltage-dependent K+ (Kv) channels characterized by having six (S1-S6) transmembrane domains and a positively charged S4 domain. As Kv channels, BK channels contain a S4 domain, but they have an extra (S0) transmembrane domain that leads to an external NH2-terminus. The BK channel is activ...
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The complexity of mammalian physiology requires a diverse array of ion channel proteins. This diversity extends even to a single family of channels. For example, the family of Ca2+-activated K channels contains three structural subfamilies characterized by small, intermediate, and large single channel conductances. Many cells and tissues, including neurons, vascular smooth muscle, endothelial c...
متن کاملOveractive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel.
BK large conductance voltage- and calcium-activated potassium channels respond to elevations in intracellular calcium and membrane potential depolarization, braking excitability of smooth muscle. BK channels are thought to have a particularly prominent role in urinary bladder smooth muscle function and therefore are candidate targets for overactive bladder therapy. To address the role of the BK...
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The homologous Kunitz inhibitor proteins, bovine pancreatic trypsin inhibitor (BPTI) and dendrotoxin I (DTX-I), interact with large conductance Ca2+-activated K+ channels (maxi-KCa) by binding to an intracellular site outside of the pore to produce discrete substate events. In contrast, certain homologues of the Shaker ball peptide produce discrete blocking events by binding within the ion cond...
متن کاملRole of the β1 Subunit in Large-Conductance Ca2+-Activated K+ Channel Gating Energetics
Over the past few years, it has become clear that an important mechanism by which large-conductance Ca(2+)-activated K(+) channel (BK(Ca)) activity is regulated is the tissue-specific expression of auxiliary beta subunits. The first of these to be identified, beta1, is expressed predominately in smooth muscle and causes dramatic effects, increasing the apparent affinity of the channel for Ca(2+...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.033506