(5) Primary Amyliodosis with Monoclonal Gammopathy and Bence-Jones Protein in Urine
نویسندگان
چکیده
منابع مشابه
Bence Jones protein in primary systemic amyloidosis.
The recent population-based study by Kyle et al,’ which was the first to provide precise epidemiologic information about primary systemic amyloidosis, reported the demonstration of a monoclonal (M)protein in the serum or urine from 16 of 21 patients (76%) with amyloid of unequivocal Ig origin (AL). However, the number of patients in whom free monoclonal Ig light chain (ie, Bence Jones [BJ] prot...
متن کاملWhat's in a name? Bence Jones protein
Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
متن کاملBence Jones proteins identified by immunofixation electrophoresis of concentrated urine.
addressed some recently recognized problems in testing concentrated urine for monoclonal free light chains of immunoglobulins, i.e., Bence Jones protein (BJP), by high-resolution elec-trophoresis (lIRE) and immunofix-ation electrophoresis (IFE). When BJP is present in low concentrations, poly-clonal free light chains can interfere with identification of the protein either by causing a dense bac...
متن کاملThe Fate of Injected Bence Jones Protein
Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only...
متن کاملPrimary Amyloidosis with Plasmacytic Dyscrasia and a Tetramer of Bence Jones Type Lambda Globulin in the Serum and Urine
An abnormal protein has been isolated ported occurrence of a urinary Bence from both the serum and urine of a paJones tetramer. The sedimentation coeftient with generalized amyloidosis and ficient of the protein was 5.OS, and its plasmacytic dyscrasia. Immunological molecular weight 79,000. Reduction and and biochemical techniques were used to alkylation, electrophoresis, and ultracendemonstrat...
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ژورنال
عنوان ژورنال: Japanese Journal of Medicine
سال: 1973
ISSN: 0021-5120,1881-123X
DOI: 10.2169/internalmedicine1962.12.238