(4R*,5R*)-2-(4-Methoxyphenyl)-1,3-dioxolane-4,5-dicarboxamide

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(4S,5S)-2-(4-Chloro­phen­yl)-1,3-dioxolane-4,5-dicarboxamide

The title compound, C(11)H(11)ClN(2)O(4), is an important inter-mediate for the preparation of platinum anti-cancer drugs. The dioxolane ring adopts a twist conformation with an equatorially attached chloro-phenyl substituent. In the crystal structure, mol-ecules are linked into a two-dimensional network parallel to (001) by N-H⋯O and C-H⋯O hydrogen bonds.

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(4R*,5R*)-2-(4-Meth­oxy­phen­yl)-1,3-dioxolane-4,5-dicarboxamide

In the title compound, C(12)H(14)N(2)O(5), the five-membered 1,3-dioxolane ring has a twisted conformation. In the crystal, N-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into a two-dimensional network lying parallel to the ab plane. There are also C-H⋯π inter-actions present in the crystal structure.

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(4S,5S)-2-(2-Bromo­phen­yl)-1,3-dioxolane-4,5-dicarboxamide

The asymmetric unit of the title compound, C(11)H(11)BrN(2)O(4), contains two crystallographically independent mol-ecules in which the bromo-phenyl rings are oriented at dihedral angles of 39.28 (3)°. The dioxolane rings adopt envelope conformations. Intra-molecular N-H⋯O hydrogen bonds result in the formation of four five-membered rings, having planar and envelope conformations. In the crystal...

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(4S,5S)-2-(2-Fluoro­phen­yl)-1,3-dioxolane-4,5-dicarboxamide

In the mol-ecule of the title compound, C(11)H(11)FN(2)O(4), the five-membered ring adopts an envelope conformation. An intra-molecular N-H⋯F hydrogen bond occurs. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules.

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(4S,5S)-2-(2-Thien­yl)-1,3-dioxolane-4,5-dicarboxamide

In the title compound, C(9)H(10)N(2)O(4)S, which is an important inter-mediate for the preparation of anti-tumor platinum drugs, the dioxolane ring adopts an envelope conformation with the C atom bonded to the thienyl ring at the flap position. Intra-molecular N-H⋯O and C-H⋯O hydrogen bonds result in the formation of two five-membered rings having envelope conformations. In the crystal structur...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online

سال: 2012

ISSN: 1600-5368

DOI: 10.1107/s1600536812002401