462 DHODH inhibition for chemoprevention and combination therapy of UVB-induced epithelial oncogenesis
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چکیده
منابع مشابه
Oral Oncogenesis and Chemoprevention
Despite considerable progress in the prevention, detection, and treatment of several cancers, most oral squamous cell carcinomas are detected in the advanced stages. In addition, the multistep process of oral oncogenesis involving accumulation of genetic alterations is complex and not yet fully understood. This short review focuses the current understanding oral oncogenesis, biomarkers, chemopr...
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Sunlight-induced non-melanoma skin cancer is the most prevalent cancer in the United States with more than two million cases per year. Several studies have shown an inhibitory effect of caffeine administration on UVB-induced skin cancer in mice, and these studies are paralleled by epidemiology studies that indicate an inhibitory effect of coffee drinking on non-melanoma skin cancer in humans. S...
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p.p1 {margin: 0.0px 0.0px 10.0px 0.0px; font: 10.0px 'Times New Roman'; color: #000000; -webkit-text-stroke: #000000} span.s1 {font-kerning: none} Presently drugs that are available to treat the diabetic induced cognitive impairment presents adverse effect on long term used. This study offers evidence that old drugs can be combined and used. Existing and affordable drugs can be repurposed a...
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15 صفحه اولInhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.
Sulforaphane is an isothiocyanate derived from cruciferous vegetables that has been linked to decreased risk of certain cancers. Although the role of sulforaphane in the induction of the transcription factor Nrf2 has been studied extensively, there is also evidence that inhibition of the transcription factor activator protein-1 (AP-1) may contribute to the chemopreventive properties of this com...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.512