410 Cartilage oligomeric matrix protein (COMP) negatively influences keratinocyte proliferation via α5β1-integrin: Potential relevance of altered COMP expression in psoriasis
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چکیده
منابع مشابه
Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
متن کاملThyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.
BACKGROUND we previously demonstrated the presence of high levels of thyroid hormones (THs) receptors isoforms in healthy tendons, their protective action during tenocyte apoptosis, and the capability to enhance tenocyte proliferation in vitro. In the present study we tested the ability of THs to influence ECM protein tenocyte secretion in an in vitro system. METHODS primary tenocyte-like cel...
متن کاملEffect of Cartilage Oligomeric Matrix Protein (comp) on Chondrogenesis in Vitro
Introduction: Cartilage oligomeric matrix protein (COMP) is an N-terminal disulfide-linked, 524 kd homopentameric glycoprotein found primarily surrounding chondrocytes in the cartilage extracellular matrix. COMP gene mutations have been identified in two types of autosomal dominant chondrodysplasias that exhibit osteoarthritic phenotypes; pseudoachondroplasia (PSACH) and multiple epiphyseal dys...
متن کاملAnalysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids.
We investigated the expression of cartilage oligomeric matrix protein (COMP) in normal and rheumatoid arthritis (RA) synovial fibroblasts. In situ hybridization (ISH) was conducted on synovial specimens from five RA patients applying specific probes for COMP or fibroblast collagen type I. ISH was combined with immunohistochemistry, applying antibodies to the macrophage marker CD68. Ribonuclease...
متن کاملTrinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene.
Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are two human autosomal dominant skeletal dysplasias characterized by variable short stature, joint laxity and early-onset degenerative joint disease. Both disorders can result from mut-ations in the gene for cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein. About one-third of PSACH cases result...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.412