4029 Stromelysin-1 as a biomarker for acute lung injury

RAGE: a biomarker for acute lung injury.

Netrin-1: a potential universal biomarker for acute kidney injury.

ACUTE KIDNEY INJURY (AKI) is commonly associated with high mortality and morbidity rates, which strongly depend on the time of the diagnosis to allow therapeutic interventions. Recent studies clearly indicate that routine assessments of kidney function based on serum creatinine and blood urea nitrogen measurements and a fall in urine output are outdated because they fail to identify early stage...

Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.

Drug-induced nephrotoxicity is a serious problem in patients with hospital-acquired acute kidney injury (AKI). A new renal biomarker is needed because traditional markers are not sensitive for early detection of drug-induced AKI. In a recent study, we demonstrated that vanin-1 is a novel candidate biomarker of nephrotoxicant-induced kidney injury. The objective of the present study is to determ...

I-FABP as Biomarker for the Early Diagnosis of Acute Mesenteric Ischemia and Resultant Lung Injury

Acute mesenteric ischemia (AMI) is a life-threatening condition that can result in multiple organ injury and death. A timely diagnosis and treatment would have a significant impact on the morbidity and mortality in high-risk patient population. The purpose of this study was to investigate if intestinal fatty acid binding protein (I-FABP) and α-defensins can be used as biomarkers for early AMI a...

Transforming Growth Factor-beta1 as Lung Injury Biomarker: a Review

Lung injury, induced by chemicals, radiotherapy or others agents is marked by enhancement in the expression of transforming growth factor beta1 (TGF-1) as a result of inflammation. TGF-1 appears to be the major profibrogenic cytokine which regulates the production and deposition of the major extracellular matrix molecules (ECM) and has been reported to be involved in a host of cellular respon...