#4018 CHARACTERISATION OF THE CLINICAL, HUMANISTIC AND ECONOMIC BURDEN OF ANAEMIA IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC LITERATURE REVIEW

Abstract Background and Aims Chronic kidney disease (CKD) is defined as structural damage and/or decreased function (glomerular filtration rate <60mL/min/1.73 m2) persisting for ≥3 months [1]. Anaemia a frequent CKD comorbidity associated with increased cardiovascular (CV) morbidity, mortality, reduced health-related quality of life (HRQoL) greater healthcare resource utilisation (HRU) [2]. Our systematic literature review provided an overview the clinical, humanistic economic burden anaemia CKD. Method A search was performed in MEDLINE, EMBASE, MEDLINE IN-PROCESS, Cochrane Controlled Trials Register Database Systematic Reviews from database inception to 10 April 2022, using predefined criteria identify cohort, cross-sectional, observational cost studies, evaluations, conceptual model reviews (complemented by grey congress abstract searches back-referencing relevant papers [2016–2021]). Full-text selected citations were examined two independent reviewers. Clinical parameters included progression, differences progression between patients with/without anaemia, time blood transfusion association stage/progression CV outcomes or mortality. Humanistic HRQoL caregiver burden. Economic determined HRU direct/indirect costs. Results Data extracted 115 studies (12,109 records, 79 supplementary items; Figure 1), including patients: pre- non-dialysis (n = 61), on dialysis 21), mixed non-/on 19) unknown status 14). Incidence advanced significantly higher adult dependent (NDD) vs those without (incidence per 1000 person-years: 15 ∼85 3 ∼25). Patients had risk than e.g. stage 1–5 adults ∼double developing end-stage (hazard ratio [95% confidence interval [CI]] 2.08 [1.50–2.89]). Median initiation lower NDD (45.1 68.3 p<0.01). proportion progressed 4 5 over follow-up periods 1, 2 years (40% 20%; 60% 25%; 75% 30%, respectively). Available data 43 reporting suggested worse anaemia; 36-item QoL scores symptoms/problems, effect- burden-of Comparative limited. Limited available evidence perspective without. has ∼2 times hospitalisation due heart failure (crude incidence CI] 1.9 [1.6–2.1]). Similarly, hospitalisations (adjusted relative [ARR] 1.33 [1.31–1.34]) emergency department visits (ARR 1.14 [1.12–1.15]) multivariate logistic regressions model. No change inter-relationships humanistic/economic parameters. There no published models illustrates identified relationships Conclusion Based limited moderate-to-good data, we found that face burdens HRU. also progression.