(4) Auto-oxidative Damage in SLE, RA and Behcet''s Disease

Symptom management in Behcets disease.

OBJECTIVE To determine the symptoms experienced by patients diagnosed with Behcet's Disease and how they cope with them. METHODS The qualitative study was conducted from September 2013 to March 2014 at Ege University Medical Faculty Hospital, Turkey, comprising patients having all symptoms of Behcet's Disease. Data was collected through semi-structured focus-group interview form. The findings...

Role of Cytokines in Behcets Disease

Behcets disease (BD) is considered a chronic relapsing multisystem inflammatory disorder. It has a worldwide distribution, but it is more prevalent in Mediterranean countries. Although its etiopathogenesis remains elusive, Immunological investigations have demonstrated the presence of immune dysregulation among the patients with BD. The disease is characterized by infiltration of lymphocytes an...

Oxidative damage in Parkinson's disease.

Free Radicals, Oxidative Stress and Oxidative Damage in Parkinson's Disease

Parkinson’s disease (PD) is an adult-onset disease of unknown etiology, with a prevalence of 0.3% in the entire population, affecting more than 1% of humans over 60 years of age. Primary degeneration occurs in pigmented dopamine-containing neurons in the pars compacta of the substantia nigra, with projections to the striatum and typical motor signs that appear with a loss of 60% of the dopamine...

Oxidative DNA damage: mechanisms, mutation, and disease.

Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to th...