4-1BB/4-1BBL signaling pathway in patients with influenza A (H1N1) virus-associated pneumonia

نویسندگان

چکیده

Aim. To evaluate the activity of 4-1BB/4-1BBL signaling pathway in patients with influenza A (H1N1) virus-associated pneumonia. Materials and Methods. Here we enrolled 85 (41 males 44 females, median age 48 (36-62) years) Among exclusion criteria were unstable hemodynamics, BMI > 30, diabetes mellitus, HIV, tuberculosis, cancer. Control group consisted 15 healthy donors. The diagnosis / H1N1 was confirmed by a positive PCR test. Pneumonia diagnosed according to Federal Clinical Guidelines «Community-acquired pneumonia adults». Severity evaluated using CURB-65 SMART-COP scales as well IDSA/ATS criteria. Plasma concentration 4-1BB (CD137 or TNFRSF9, an inducible costimulatory receptor expressed on activated T cells antigen-presenting cells) determined flow cytometry. Results. Patients moderate severe had 1.5- 2.4 fold-increased plasma 4-1ВВ compared controls. Conclusion. pathway, involved multiple immune reactions, is associated severity

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ژورنال

عنوان ژورنال: ??????????????? ? ??????????? ????????

سال: 2022

ISSN: ['2542-0941', '2500-0764']

DOI: https://doi.org/10.23946/2500-0764-2022-7-1-64-69