منابع مشابه
The antithrombin activity of heparin.
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متن کاملMolecular weight analysis of antithrombin III-heparin and antithrombin III-thrombin-heparin complexes.
The molecular interactions between components of the heparin-catalyzed antithrombin III/thrombin reaction were investigated by light scattering. When heparin was added to antithrombin III, the molecular weight increased to a maximum and then decreased to that of a 1:1 (antithrombin III X heparin) complex. The initial molecular weights at low heparin to antithrombin III ratios were consistent wi...
متن کاملThe antithrombin-binding sequence of heparin.
Products obtained by partial depolymerization of pig mucosal heparin with nitrous acid were fractionated by affinity chromatography on immobilized antithrombin. A high affinity octasaccharide fraction was recovered and reduced with sodium [3H]borohydride, yielding terminal 2,5-anhydro-~-[l-~H]mannitol residues. Partial N-desulfation of this material by treatment with aqueous dimethylsulfoxide r...
متن کاملScreening for heparin binding variants of antithrombin.
A chromogenic assay for use as a screening test for the identification of antithrombin deficiency is described. The heparin concentration and the incubation time in the assay were optimised specifically to permit the detection of heparin binding defects of antithrombin. The sensitivity of antithrombin assays for the detection of this type of variant was significantly impaired when an incubation...
متن کاملCircular dichroism spectroscopy of heparin-antithrombin interactions.
We have utilized circular dichroism spectroscopy to examine the interaction of antithrombin with heparin-derived oligosaccharides and mucopolysaccharides of various sizes. Our studies demonstrate that the various complexes exhibit two major types of chiral absorption spectra. The first of these patterns is seen when octasaccharide, decasaccharide, dodecasaccharide, or tetradecasaccharide fragme...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1977
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.8.639