3D Silk Fiber Construct Embedded Dual-Layer PEG Hydrogel for Articular Cartilage Repair – In vitro Assessment
نویسندگان
چکیده
منابع مشابه
Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair
Delivery of bioactive factors is a very valuable strategy for articular cartilage repair. Nevertheless, the direct supply of such biomolecules is limited by several factors including rapid degradation, the need for supraphysiological doses, the occurrence of immune and inflammatory responses, and the possibility of dissemination to nontarget sites that may impair their therapeutic action and ra...
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Human articular cartilage is highly susceptible to damage and has limited self-repair and regeneration potential. Cell-based strategies to engineer cartilage tissue offer a promising solution to repair articular cartilage. To select the optimal cell source for tissue repair, it is important to develop an appropriate culture platform to systematically examine the biological and biomechanical dif...
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Articular cartilage lesions in the young population predispose to the development of precocious osteoarthritis. Poor healing of cartilage damaged by trauma or degeneration has been ascribed to avascularity. Cartilage lesions are associated with significant morbidity, including lifestyle restrictions, especially in individuals engaged in sports. The past decade has seen the evolution of a number...
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Explants are excellent systems for studying homeostasis in cartilage. The systems are very useful in pharmacological studies involving OA-treatment and in studies of repair mechanisms during injury to hyaline cartilage. The purpose of this study was to evaluate the reparative processes occurring in a young age porcine cartilage explant model examining tissue by Light (LM) and Transmission Elect...
متن کاملArticular Cartilage Repair
This review traces the genealogy of the field of articular cartilage repair from its earliest attempts to its present day vast proliferation of research advances. Prior to the 1980s there was only sporadic efforts to regenerate articular cartilage as it was considered to be incapable of regeneration based on historical dogma. The first flurry of reports documented the use of various cell types ...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2021
ISSN: 2296-4185
DOI: 10.3389/fbioe.2021.653509