3D-QSAR Study of Potent Inhibitors of Phosphodiesterase-4 Using a CoMFA Approach
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چکیده
منابع مشابه
3D-QSAR Study of Potent Inhibitors of Phosphodiesterase-4 Using a CoMFA Approach
Phosphodiesterase-4 (PDE4) plays an important role in treatment of asthma and chronic obstructive pulmonary disease. Thirty-one analogs displaying variable inhibition of PDE4 were selected to develop models for establishing three-dimensional quantitative structure-activity relationships (3D-QSAR). Comparative molecular field analysis (CoMFA) was conducted on the group of analogs to determine th...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2007
ISSN: 1422-0067
DOI: 10.3390/i8070714