394 Potential disease-severity-related alterations in the uninvolved psoriatic skin

Data suggest that in psoriasis the entire epidermis of individuals has inherited capacity to form lesions. The uninvolved (UN) skin potentially provides a tissue environment which lesions can develop. Since cytokines, chemokines, proteases, and their inhibitors play important roles regulating tissue-organization, we aimed compare these proteins between healthy (H) patients with mild (mean PASI: 9.06) severe 28.93) using specific protein arrays. Proteins two-fold changes were selected used for Reactome over-representation test reveal most relevant processes affected by at least changes. Based on decreased both UN compared H skin, altered hemostasis-related identified. In mild-UN p53-regulated cell death-related extracellular matrix (ECM) degradation-related identified as primarily mechanisms relative skin. On other hand, severe-UN versus mostly influenced immune system-related pathways, while increased prominently belonged RUNX1-related transcription factor 1 functions based analysis. major difference was found ECM degradation. Decreased affect methyl-CpG-binding 2-related processes. differential expression protease emphasize not only but also psoriatic indicate possible disease-severity-related tissue-organization Further studies may whether alterations could predict potential disease outcome disease.