منابع مشابه
393Vancomycin Dosing in Obese Patients
Background. Current guidelines for systemic vancomycin dosing recommended using actual body weight (ABW) regardless of body mass index (BMI). We sought to evaluate the effect of this dosing strategy in obese patients with BMI ≥35. Methods. Retrospective cohort study of patients ≥18 years old with a BMI ≥35 hospitalized between January 1, 2011 and December 31, 2013 with at least 3 doses of intra...
متن کاملAntimicrobial dosing in obese patients.
Although the dose of some drugs is commonly adjusted for weight, weight-related dosage adjustments are rarely made for most antimicrobials. We reviewed the English-language literature on antimicrobial pharmacokinetics and dosing in obesity. Although there are many potential pharmacokinetic consequences of obesity, the actual effect on the pharmacokinetics and clinical efficacy of most antimicro...
متن کاملDosing Ethambutol in Obese Patients
Deshpande et al. conclude that ethambutol (EMB) doses of 50 mg/kg of body weight twice a week would be the optimal clinical dose for the treatment of Mycobacterium avium (2). This was based on pharmacokinetic-pharmacodynamic studies using a hollow-fiber system model of intracellular M. avium, mimicking ethambutol human-like pharmacokinetics. This adds important information on the relationship b...
متن کاملDosing Ethambutol in Obese Patients
Deshpande et al. conclude that ethambutol (EMB) doses of 50 mg/kg of body weight twice a week would be the optimal clinical dose for the treatment of Mycobacterium avium (2). This was based on pharmacokinetic-pharmacodynamic studies using a hollow-fiber system model of intracellular M. avium, mimicking ethambutol human-like pharmacokinetics. This adds important information on the relationship b...
متن کاملAn Evaluation of Systemic Vancomycin Dosing in Obese Patients
We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2014
ISSN: 2328-8957
DOI: 10.1093/ofid/ofu052.259