(371) Characterization of axonal chemical sensitivity following CFA or vinblastine treatment

Chemical characterization of the degradation products of vinblastine dihydrogen sulfate.

Vinblastine was incubated in 0.2 M glycine buffer (pH 7.4 or 8.8) containing bovine serum albumin (1%) at 37 degrees C for 72 h. The reaction mixture was extracted with CH2Cl2, and the extract gave 6 major peaks (A, B, C, D, E, and F) with retention times of 5.0, 7.5, 11.0, 13.0, 23.0, and 30.0 min, respectively, in a high-performance liquid chromatography system (muBondapak C18 column; solvent...

Chemical Characterization of the Degradation Products of Vinblastine Dihydrogen Sulfate1

MATERIALS AND METHODS Vinblastine was incubated in 0.2 M glycine buffer (pH 7.4 or 8.8) containing bovine serum albumin (1%) at 37°Cfor 72 h. The reaction mixture was extracted with CH2CI2, and the extract gave 6 major peaks (A, B, C, D, E, and F) with retention times of 5.0, 7.5, 11.0, 13.0, 23.0, and 30.0 min, respectively, in a high-performance liquid chromatography system (/¿Bondapak CÃ-a...

Chemical sensitivity: pathophysiology or pathopsychology?

BACKGROUND Escalating numbers of people throughout the world are presenting to primary care physicians, allergists, and immunologists with myriad clinical symptoms after low-level exposure to assorted everyday chemicals such as smoke, perfumes, air fresheners, paints, glues, and other products. This clinical state is referred to by various diagnostic labels, including multiple chemical sensitiv...

Red cell production in the mouse following treatment with vinblastine.

Action of the Vinca Alkaloids Vincristine, Vinblastine, and Desacetyl Vinblastine Amide on Axonal Fibrillar Organelles in Vitro1

toxicity usually involves marrow suppression, with neurop athy a relatively infrequent occurrence (16). VDS, a new Vinca alkaloid undergoing clinical trials, may cause both a neuropathy and marrow suppression (13). The factors un denying these clinical differences have not been clarified. In light of the differing clinical effects of these 3 drugs on the peripheral nervous system, we have exami...