#3625 TREATMENT OUTCOMES FOR IDIOPATHIC SUDDEN SENSORINEURAL HEARING LOSS IN DIALYSIS PATIENTS

Abstract Background and Aims Idiopathic sudden sensorineural hearing loss (ISSNHL) is one of the most challenging complications nephrologists encounter when treating dialysis patients (pts). Since no previous study has compared treatment response pts to that non-dialysis pts, physicians have difficulty managing these pts. This aimed investigate outcome with ISSNHL. Method In this single-center, retrospective, observational study, 700 diagnosed ISSNHL between January 2005 December 2021 at Asan Medical Center, Korea were enrolled. Among them, 47 653 Non-dialysis using a 5:1 propensity score matching (PSM) analysis balance pre-existing clinical characteristics. High-dose systemic steroid therapy or intra-tympanic (IT) injections administered according standard protocol. The pure tone average (PTA) two groups was before initiating treatment, after 2 weeks months treatment. degree improvement in evaluated Siegel's criteria. Results Without PSM, age, prevalence diabetes hypertension, initial threshold by each frequency level (0.5, 1, 2, 4 kHz), strategies statistically different groups. PS-matched cohort, none measured confounding variables (Table 1). Two audiometry (p = 0.025) percentage complete criteria significantly higher group than (27.2% vs. 6.4%) 2). Conclusion suggests worse outcomes for