3,3′-Diindolylmethane: A Promising Sensitizer ofγ-Irradiation

3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation

PURPOSE Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer. The present work investigated the effect of 3,3'-diindolylmethane (DIM) on γ-irradiation sensitizing human breast carcinoma. METHODS Cell survival, intracellular ROS levels, cell cycle distribution, cell apoptosis, and expression of proteins related to apoptosis were measured with MTT assays, f...

ADAM Metallopeptidase Domain 33 (ADAM33): A Promising Target for Asthma

Over the last few years, a significant progress has been made in understanding the role of a disintegrin and metalloproteinase 33 (ADAM33) in asthma. The previous observations for the association with asthma have been replicated in over 33 different population samples worldwide. We and others have performed association analysis and meta-analysis and provided further evidence that several polymo...

What makes a chemical a respiratory sensitizer?

PURPOSE OF REVIEW In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract. RECENT FINDINGS Chemical respiratory allergens share some characteristics with other chemical allergens, specifically chemical allergens that cause skin sensitization and allergic contact derm...

CPSC Staff’s Strong Sensitizer Guidance Document For a product containing a strong sensitizer

For a product containing a strong sensitizer to be considered a hazardous substance and to require cautionary labeling under the FHSA, the product must be capable of causing substantial personal injury or substantial illness during, or as a result of, customary or reasonably foreseeable handling or use, including reasonably foreseeable ingestion by children. This requires consideration of the r...

Low toxicity radiation sensitizer