326 Epidermal and dermal feed-forward inflammatory loop in psoriasis
نویسندگان
چکیده
Skin is the outmost barrier that separates human body from external environment. In psoriasis, immune cells are resident and / or infiltrated into epidermis in order to form epidermal immunological microenvironment (EIME) constitute a complex interaction with keratinocytes, together nerve microbiota influence. Our results have shown psoriasis mainly mediated by specific inflammatory environment composed keratinocyte-neuro-immune cell units (KNICUs), which of activated cells, keratinocytes peripheral nerves fibers, increased psoriatic lesions closely innervated around keratinocytes. Multiple gathering complete circulatory amplified loop, both an feed-forward loop constituted dendritic pDC, cDC, Langerhans CD8+T dermal macrophages CD4+T cells. The plays dominant role initiation maintenance psoriasis.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.331