#3148 PROTEINURIA AND TYPE OF KIDNEY ALLOGRAFT INJURY IDENTIFY KIDNEY TRANSPLANT RECIPIENTS BENEFITING MOST FROM BELATACEPT CONVERSION
نویسندگان
چکیده
Abstract Background and Aims Belatacept conversion is associated with an improvement in kidney allograft function. Yet, not all transplant recipients (KTRs) seem to benefit equally from this alteration of maintenance immunosuppression. Both type (alloimmune vs. non-alloimmune) severity (assessed by proteinuria) injury may impact the functional response a belatacept conversion. Method We studied 37 KTRs 1-year post-conversion. were categorized concerning pre-conversion proteinuria: 21 low proteinuria (<500 mg/day), 12 moderate (500–1000 4 high (>1000 mg/day). analyzed change function, proteinuria, non-alloimmune). Results 17 (81%) showed pre- post-conversion, 5 16 (31%) moderate/severe post-conversion (group 1, n = 22). 8 (67%) 1 (5%) developed 2, 9). 3 (75%) (14%) 3, 6). 22 (73%; group 1) increase eGFR at (≥10% baseline eGFR) compared 6 9 (66%, 2) (17%, 3) (p 0.008). Alloimmune was assumed (23%, 1), (33%, 2), (75%, 3), respectively. Conclusion non-alloimmune most While aggravation rare, some show If still beneficial calcineurin inhibitor-based immunosuppression among alloimmune needs be studied.
منابع مشابه
Belatacept conversion in African American kidney transplant recipients with severe renal dysfunction
OBJECTIVES Conversion from calcineurin inhibitor-based maintenance immunosuppression to belatacept in kidney transplant recipients has been demonstrated to improve renal function while maintaining efficacy against rejection. However, conversion studies to date have excluded patients with an estimated glomerular filtration rate < 35 mL/min/1.73 m2. METHODS We describe two patients with an esti...
متن کاملSignificance and management of proteinuria in kidney transplant recipients.
Proteinuria is common after kidney transplantation and typically urine protein levels are below 500 mg/d. However, even these low levels are associated with reduced graft survival. Most allografts with proteinuria >1500 mg/d have new glomerular pathology. In contrast, lower levels of proteinuria are generally associated with nonglomerular, nonspecific histologic changes. The relationship betwee...
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associated with olmesartan. Aliment Pharmacol Ther. 2014;40:16–23. 4. DeGaetani M, Tennyson CA, Lebwohl B, Lewis SK, Abu Daya H, Arguelles-Grande C, et al. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol. 2013;108:647–53. 5. Ulla-Rocha JL, Lopez-Pineiro S, Puga-Gimenez M. Acute renal failure secondary to diarrhea due to sprue like-enteropat...
متن کاملConversion of ciclosporin A to tacrolimus in kidney transplant recipients with chronic allograft nephropathy.
BACKGROUND Tacrolimus and ciclosporin might have different effects on intra-renal fibrosis and allograft function in chronic allograft nephropathy (CAN). It is difficult to predict the response to calcineurin inhibitor minimization in patients with CAN. METHODS This prospective randomized study compared ciclosporin A (CsA)-to-tacrolimus conversion (group A, target tacrolimus trough level 6-8 ...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_3148