3-Methylglutaric acid in energy metabolism
نویسندگان
چکیده
منابع مشابه
Bacterial metabolism of 3-hydroxy-3-methylglutaric acid.
An organism belonging to Pseudomonadaceae and capable of utilizing 3-hydroxy-3-methylglutarate as sole carbon source has been isolated from soil. Whole-cell preparations catalyze the oxidation of acetoacetate, acetate, glyoxylate, and citric acid cycle intermediates. Cell-free extracts of 3-hydroxy-3-methylglutarate-grown cells show an adenosine triphosphate, coenzyme A (CoA), and Mg(2+)-depend...
متن کاملThe lipid-lowering effects of 3-hydroxy-3-methylglutaric acid and bile acid drainage in WHHL rabbits.
The effect of 3-hydroxy-3-methylglutaric acid (HMG) on serum cholesterol levels was investigated in Watanabe heritable hyperlipidaemic (WHHL) rabbits. Oral administration of HMG resulted in a reduction of serum cholesterol by 39%. Bile acid drainage, by means of either cholestyramine medication or partial ileal bypass (PIB) surgery, also led to significant reductions in circulating cholesterol,...
متن کامل3-hydroxyanthranilic Acid Metabolism
The participation of 3-hydroxyanthranilic acid as an intermediate in the biosynthesis of nicotinic acid from tryptophan was first demonstrated in certain mutant strains of Neurospora in 1948 by Bonner (1) and by Mitchell and Nyc (2). In addition, Mitchell et al. (3) found that 3-hydroxyanthranilic acid can replace nicotinic acid in the nutrition of the rat. In 1946 Singal et al. (4) noted a sub...
متن کاملn-3 fatty acid metabolism in women.
Using a stable-isotope tracer technique, Burdge & Wootton (2002) noted that women of child-bearing age (about 28 years) had a much greater capacity to convert a-linolenic acid (18 : 3n-3) to docosahexaenoic acid (22 : 6n-3) compared with men of a similar age (Burdge et al. 2002). Based on their analysis of the area under the curve of the time course plot of the plasma C-labelled fatty acids, th...
متن کاملSeparation of ( 3 . 14 C ) 3 - Hydroxy . 3 - methylglutaric acid from ( 3 _ 14 C ) 3 - Hydroxy - 3 - methylglutaryl CoA using Sephadex G - 15 column chromatography
A new method has been developed for the separation of (314C) 3-Hydroxy-3-methylglutaric acid from a (3_ 14C) 3-Hydroxy-3-methylglutaryl CoA preparation using Sephadex G-15 column chromatography. This method is simple, rapid and is useful in studies whe1'e the preparation of (3_ 14C) 3-Hyd1'oxy-3-methylglutaryl CoA is requi1'ed to bef1'eef1'Om (3_ 14C) 3-Hyd1'oxy-3-methylgluta1'ic acid contamina...
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ژورنال
عنوان ژورنال: Clinica Chimica Acta
سال: 2020
ISSN: 0009-8981
DOI: 10.1016/j.cca.2019.11.006