3β-Azidoformate thermolysis as a method for functionalizing the 4α-methyl group of lanostan-3β-ol and similar systems
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چکیده
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19β,28-Epoxy-18α-olean-3β-ol
The title triterpene, C(30)H(50)O(2), is an 18α-oleanane derivative prepared by the Wagner-Meerwein rearrangement of betulin with Bi(OTf)(3).xH(2)O (OTF is trifluoromethanesulfonate). There are two symmetry-independent mol-ecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformation of the six-membered rings is close to a chair form, wh...
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The first total synthesis of ergosta-5,8-dien-3β-ol, an uncommon sterol previously isolated from an alga and several microorganisms, has been developed. For the first time, a full set of spectroscopic data of this sterol is presented.
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In the title compound, C(21)H(30)N(2)O, there are five fused rings. The A and C rings adopt chair conformations, ring B adopts an 8β,9α-half-chair conformation and ring D adopts a 14α-envelope conformation. The pyrazole ring is planar. Inter-molecular O-H⋯N hydrogen bonds [H⋯N = 1.88 (5) Å] help to stabilize the crystal structure. The absolute structure was deduced from those of the starting ma...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1977
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v77-345