3'', 4''-DIDEOXY-KANAMYCIN B ACTIVE AGAINST KANAMYCIN-RESISTANT ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA
نویسندگان
چکیده
منابع مشابه
Synthesis of 3',4'-dideoxy and 3',4',5''-trideoxyribostamycin active against kanamycin-resistant E. coli and P. aeruginosa.
cin B2) and S'^-dideoxyneamine^ have confirmed that removal of the hydroxyl group which is phosphorylated by drug-resistant bacteria from kanamycins gives compounds active against the resistant organisms. As an extension of this work, we describe in this paper the syntheses of two deoxy-derivatives of ribostamycin4). If inactivation of ribostamycin by Escherichia coli K12-ML 1629 and K12-ML 163...
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Sir: The enzymatic mechanism of resistance to aminoglycoside antibiotics has been explored by UMEZAWA.1,2) Many clinically isolated strains of aminoglycosides-resistant bacteria produce enzymes which phosphorylate, adenylylate or acetylate specific positions of aminoglycoside antibiotics. Kanamycin and kanamycin B are inactivated by aminoglycoside 3'-phosphotransferases, 2"-nucleotidyltransfera...
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Both kanamycin A and kanamycin B, antibiotic components produced by Streptomyces kanamyceticus, have medical value. Two different pathways for kanamycin biosynthesis have been reported by two research groups. In this study, to obtain an optimal kanamycin A-producing strain and a kanamycin B-high-yield strain, we first examined the native kanamycin biosynthetic pathway in vivo. Based on the prop...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1971
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.24.485