2D & 3D QSAR AND DRUG DESIGNING OF PHENOTHIAZINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS
نویسندگان
چکیده
منابع مشابه
3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کامل3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کامل3d qsar studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against mycobacterium tuberculosis h37rv (atcc 27294). in this paper we report 3d qsar studies for the 41 molecules of 1,3,4-oxadiazoles by using k-nearest neighbor molecular field analysis...
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A set of forty one substituted-2-phenyl-benzimidazole derivatives with anti-allergic activity was subjected to the two dimensional quantitative structure activity relationships studies using V life molecular design suite 3.5. Drug Designing module contain various combinations of thermodynamic, electronic, topological and spatial descriptors.Substituted-2-phenyl-benzimidazole was taken as the le...
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In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...
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ژورنال
عنوان ژورنال: World Journal of Pharmaceutical Research
سال: 2017
ISSN: 2277-7105
DOI: 10.20959/wjpr20178-9099