25-Hydroxyvitamin D: A Difficult Analyte

25-hydroxyvitamin D: a difficult analyte.

In their article in the current issue of Clinical Chemistry, Farrell et al. (1 ) describe the latest in a number of studies (2, 3 ) highlighting the method-related variability in serum 25-hydroxyvitamin D (25-OHD) results. There is common agreement that 25-OHD is a “difficult” analyte. That quality is generally ascribed to its hydrophobic nature, its existence in several different molecular for...

Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents.

BACKGROUND There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied....

25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation.

Vitamin D deficiency may have implications for cardiovascular health. The purpose of this study was to determine the relationship of 25-hydroxyvitamin D (25[OH]D) to cholesterol and lipoprotein particles and to determine whether increasing 25(OH)D through ultraviolet (UV) irradiation impacted on these parameters in healthy young men and women. This was a randomized trial of 51 adults exposed to...

25-Hydroxyvitamin D and calcium absorption.

Correlates of Circulating 25-Hydroxyvitamin D

Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating ...