243 Targeting S. aureus biofilm with leave-on emollients containing oligofructants and acetyl heptapeptide-4 complex

Increased Staphylococcus aureus colonisation is associated with atopic eczema (AE) severity. Reduction of S. levels, especially in AD patients, may led to an improvement the skin condition. Thus, aim a study was evaluate reduction od biofilm formation, two emollients for face and body care (no. 19624 19625 respectively). They contained complex ingredients (oligofructants from Ophiopogon japonicus acetyl heptapeptide-4). Moreover safety tolerability mentioned products were evaluated. Bacterial suspensions strains MSSA (83254), MRSA (BH1CC) epidermidis (RP62A 1457) mixed incubated several dilutions tested 24 hrs, next stained crystal violet. MTT cytotoxicity vitro (L929 cells) irritation potential ex vivo on EpiDerm model measured according ISO 10993. In addition this, severity occurence flares-up children preliminary studies comparison topical medical treatement. Both reduced formation different impact epidermidis. Also did not show towards L929 cells. this demonstrated that after 7 days emollient therapy comparable treatement corticosteroids. biocompatible well-tolerated. be considered as effective Emollient Plus type devices reduce patients suffering eczema/dermatitis.