225 WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS
نویسندگان
چکیده
منابع مشابه
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced de-differentiation of human articular chondrocytes through simultaneous activation of β-catenin-dependent and independent responses. WNT-3A activates both the β-catenin-dependent canonical pathway and the Ca(2+)/CaMKII n...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2010
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(10)60252-x