216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation
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چکیده
منابع مشابه
6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice
Ginger (Zingiber officinale) has been traditionally used to check hair loss and stimulate hair growth in East Asia. Several companies produce shampoo containing an extract of ginger claimed to have anti-hair loss and hair growth promotion properties. However, there is no scientific evidence to back up these claims. This study was undertaken to measure 6-gingerol, the main active component of gi...
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102 Ann Dermatol Received September 24, 2015, Revised December 8, 2015, Accepted for publication December 14, 2015 Corresponding author: Young Kwan Sung, Department of Immunology, Kyungpook National University School of Medicine, 680 Gukchaebosangro, Jung-gu, Daegu 41944, Korea. Tel: 82-53-420-4874, Fax: 82-53-423-4628, E-mail: [email protected] This is an Open Access article distributed under th...
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Hair follicle stem cells in the hair follicle bulge area of mice are nestinand CD34-positive, and keratin 15 (K15)negative. The mouse hair follicle stem cells are multipotent and can differentiate into neurons, glial cells, keratinocytes, smooth muscle cells, and melanocytes (Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005). Recently, pluripotent stem cells have been identified in human hair fo...
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Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent ...
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The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.235