204P Attenuated MMR and CIN pathway promote CRC progression through CDC25A upregulation: role of DNMT inhibitors
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منابع مشابه
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15 صفحه اولRapid synthesis of new DNMT inhibitors derivatives of procainamide.
DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compounds resulted in potent inhibitors of the murine catalytic Dnmt3A/3L complex and of human DNMT1, at least 50 times greater than that of the pare...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1016/s0923-7534(21)00362-8