20-Hydroxy-4, 8, 13, 17-tetramethyl-4, 8, 12, 16-eicosatetraenoic Acid, a New Feeding Deterrent against Herbivorous Gastropods, from the Subtropical Brown Alga <i>Turbinaria ornata</i>

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Winter : synergistic effect of cells from the adult heart

Macrophage Hydroxy - Eicosatetraenoic Acid Metabolism

Mouse resident macrophages are potent sources of arachidonic acid (20:4) 1 metabolites generated via both the cyclooxygenase and lipoxygenase pathways (1-5). The phospholipids of this cell are highly enriched with 20:4, and upon appropriate membrane stimulation, up to 50% of endogenous 20:4 is released and metabolized to a mixture of prostaglandins, hydroxy-eicosatetraenoic acids (HETEs), and l...

12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor.

The aryl hydrocarbon receptor (AHR) is a ligand-regulated transcription factor that can be activated by structurally diverse chemicals, ranging from environmental carcinogens to dietary metabolites. Evidence supporting a necessary role for the AHR in normal biology has been established; however, identification of key endogenous ligand/activator remains to be established. Here, we report the abi...

Synthesis of new 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone moiety containing 4-thiazolidinone moiety

A series of novel 1, 8-dioxo-octahydroxanthene derivatives containing 4-thiazolidinone framework (4a-f) were synthesized through a four-step reaction starting from the reduction of nitro derivatives of 1, 8-dioxo-octahydroxanthenes. The resulting aminoxanthenes converted to thiourea derivatives via their reaction with methyl isothiocyanate. The final products were synthesized through the re...

SYNTHESIS OF 8-HYDROXY-6-METHOXY- 3-UNDECYLISOCOUMARIN AND 2-HY DROXY - 4-METHOXY-6-(2-OXOTRIDECYL) BENZOIC ACID

Straightforward conversion of (+)-6,8-dimethoxy-3,4-dihydro-3- undecylisocoumarin (3) to the title isocoumarin was carried out. Hydrolytic ring opening of (3) afforded the hydroxy acid (4) which was immediately oxidized to keto acid (5) using chromic acid, Cyclodehydration of (5) afforded the 6,8- dimethoxy-3-undecylisocoumarin (6) which on selective demethylation of 8- methoxy group furni...