2. Antibiotics Directed against Solid Tumors
نویسندگان
چکیده
منابع مشابه
Cytotoxicity of activated natural killer cells against pediatric solid tumors.
PURPOSE To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. EXPERIMENTAL DESIGN We tested in vitro cytotoxicity of expand...
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© 2012 Nabil F. Saba et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License ( http://creativecommons.org/licenses/by/3.0/), which permits distribution, public display, and publicly performance, making multiple copies, distribution of derivative works, provided the original work is properly cited. This license requires copyright...
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Neuroblastoma is the most common non-CNS tumor in children. Poor prognosis for patients presenting with highrisk disease underlines the need for novel therapeutic strategies. Chimeric antigen receptor T cell (CART) therapies combine the epitope specificity of a monoclonal antibody with the cytotoxicity of an activated T cell, and have demonstrated clinical efficacy in pediatric leukemia. To exp...
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The efficacy of molecular therapies for human malignancies is limited by inadequate accumulation within solid tumors. Our laboratory has developed a novel approach that uses monoclonal antibodies (MAbs) to direct vasoactive proteins to tumor sites to increase local vascular permeability and, in turn, improve the delivery of therapeutic reagents. Previously, we demonstrated that pretreatment wit...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2009
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.98.1901