(194) Inhibition of ATF2 decreases mechanical allodynia and thermal hyperalgesia after spinal nerves ligation
نویسندگان
چکیده
منابع مشابه
Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats
BACKGROUND We have previously shown a sprouting of sympathetic fibers into the upper dermis of the skin following subcutaneous injection of complete Freund's adjuvant (CFA) into the hindpaw. This sprouting correlated with an increase in pain-related sensitivity. We hypothesized that this sprouting and pain-related behavior were caused by an increase in nerve growth factor (NGF) levels. In this ...
متن کاملCorrection: Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats
Correction It was brought to my attention that the representative bands on Figure 1A, of this work [1] are from a different experiment than the one described and do not represent the quantified data. The quantification and bar graphs are correct, but the representative bands should be replaced by the ones from the corresponding experiment. The error was made during figure preparation. We apolog...
متن کاملMicroinfusion of TNFα and its antibody into locus coeruleus modifies nerve injury induced thermal hyperalgesia and mechanical allodynia
Introduction: Glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. Although changes in TNFα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. We investigated the effect of microinfusion of TNFα into the LC in a rat model of neuropathic pain. Methods: Male Wistar rats...
متن کاملInteraction of NMDA and opioid receptors on thermal hyperalgesia and mechanical allodynia in two models of neuropathic pain
The use of multiple loose ligations of the rat sciatic nerve has been proposed as a model for the study of allodynia and hyperalgesia. This pain hypersensitivity results from both an increase in the peripheral and central sensitization. The evidence indicating that the development of neuropathic thermal hyperalgesia and mechanical allodynia requires activation of spinal cord NMDA receptors. NMD...
متن کاملInteraction of NMDA and opioid receptors on thermal hyperalgesia and mechanical allodynia in two models of neuropathic pain
The use of multiple loose ligations of the rat sciatic nerve has been proposed as a model for the study of allodynia and hyperalgesia. This pain hypersensitivity results from both an increase in the peripheral and central sensitization. The evidence indicating that the development of neuropathic thermal hyperalgesia and mechanical allodynia requires activation of spinal cord NMDA receptors. NMD...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2017
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2017.02.101