18F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia
نویسندگان
چکیده
منابع مشابه
Teaching NeuroImages: Nonfluent variant primary progressive aphasia
A 66-year-old woman presented with 4 years of progressive speech difficulty. She had nonfluent speech with phonemic errors but intact single-word comprehension and object knowledge. Her grammar was impaired in both speech and writing, and she exhibited orofacial apraxia. A clinico-radiologic (see figure) diagnosis of nonfluent variant primary progressive aphasia was made. Nonfluent variant prim...
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BACKGROUND/AIMS Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. METHOD We assessed grammat...
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OBJECTIVE The semantic variant of primary progressive aphasia (svPPA) is typically associated with frontotemporal lobar degeneration (FTLD) with longTAR DNA-binding protein (TDP)-43-positive neuropil threads and dystrophic neurites (type C), and is only rarely due to a primary tauopathy or Alzheimer's disease. We undertook this study to investigate the localisation and magnitude of the presumed...
متن کاملThe non-fluent/agrammatic variant of primary progressive aphasia.
The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by poor grammatical comprehension and expression and a disorder of speech sound production. In an era of disease-modifying treatments, the identification of naPPA might be an important step in establishing a specific cause of neurodegenerative disease. However, diff...
متن کاملThe new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss...
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ژورنال
عنوان ژورنال: Dementia and Neurocognitive Disorders
سال: 2018
ISSN: 1738-1495,2384-0757
DOI: 10.12779/dnd.2018.17.3.110