181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
نویسندگان
چکیده
منابع مشابه
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.
Interferon regulatory factor 5 (IRF5) regulates inflammatory M1 macrophage polarization, and disease-associated IRF5 genetic variants regulate pattern-recognition-receptor (PRR)-induced cytokines. PRR-stimulated macrophages and M1 macrophages exhibit enhanced glycolysis, a central mediator of inflammation. We find that IRF5 is needed for PRR-enhanced glycolysis in human macrophages and in mice ...
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ژورنال
عنوان ژورنال: Heart
سال: 2013
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2013-304019.181