181 Cooling for Newborns with Hypoxic Ischaemic Encephalopathy

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Cooling for newborns with hypoxic ischaemic encephalopathy.

BACKGROUND Newborn animal and human pilot studies suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae, without adverse effects. OBJECTIVES To determine whether therapeutic hypothermia in encephalopathic asphyxiated newborn infants reduces mortality and long-term neurodevelopmental disability, without clinically important sid...

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Hypothermia for newborns with hypoxic ischemic encephalopathy.

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal temperature of 34±0.5°C initiated as soon as possible within the first 6 h of life decreases mortality and severe long-term neurodevelopmental disabilities in infants with moderate HIE who are ≥36 weeks' gestational ag...

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Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy.

There is now a strong evidence base supporting therapeutic hypothermia for infants with moderate or severe neonatal hypoxic ischaemic encephalopathy. Experimental and clinical data indicate that induced hypothermia reduces cerebral hypoxic ischaemic injury and randomized clinical trials in newborns with hypoxic ischaemic encephalopathy confirm improved neurological outcomes and survival at 18 m...

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Passive hypothermia (≥35 - <36°C) during transport of newborns with hypoxic-ischaemic encephalopathy

BACKGROUND Hypothermia initiated in the first six hours of life in term infants with hypoxic ischemic encephalopathy reduces the risk of death and severe neurological sequelae. Our study's principal objective was to evaluate transport predictors potentially influencing arrival in NICU (Neonatal Intensive Care Unit) at a temperature ≥35-<36°C. METHODOLOGY/PRINCIPAL FINDINGS A multi-centric, pr...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 2005

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-200508000-00210