175 Impact of childhood atopic dermatitis on cognition and achievement

Atopic dermatitis (AD) often arises in early childhood during a critical period of cognitive development and has been linked to attention deficit hyperactivity disorder, sleep disruptions, neuropsychiatric comorbidities. However, less is known about the impact AD on cognition academic achievement. In birth cohort U.S. children followed Study Early Child Care Youth Development from 1991 2007, we conducted retrospective study comparing 116 with 1,104 without respect Wechsler Abbreviated Scale Intelligence 4th grade Woodcock-Johnson-Revised (WJ-R) tests achievement 3rd 5th grades. was assessed at 36 months old, 54 1st grade; caregiver report ≥2 points used define presence AD. Mean (SD) full-scale IQ 108.8 (15.3) 106.6 (14.3) non-AD groups, respectively (p=0.15). Adjusted for sex, race, ethnicity, parental education family income, not significantly associated bottom-quartile IQ<90 (OR 1.30, 95% CI 0.58-2.91). standard scores WJ-R Broad Math Reading did differ between groups or Using generalized estimating equations adjusted sociodemographics education, statistically low math 1.24, 0.49-3.12) reading (1.73, 0.71-4.20). Sensitivity analyses broadening definitions include caregiver-reported any single timepoint led similar results. While observe significant differences general this population likely predominantly mild AD, future studies examining larger populations including more severe using concurrent outcome measurements are needed.